R&D Approach

Our chemistry-led strategy focuses on the development of kinase inhibitors with:

  • Unique selectivity to limit target-based toxicity
  • High potency to optimise the dose selection with the objective to lower the required dose and thereby limit compound-based toxicity
  • Chemical structures deliberately engineered to improve drug exposure in the targeted tissue
  • The ability to be combined with other therapeutic agents

Hutchison MediPharma
This approach consists of two main pillars:

  1. Developing synthetic compounds against novel targets with global first-in-class potential, which includes savolitinib (targeting MET), surufatinib (targeting VEGFR/FGFR1/CSF-1R), HMPL-523 (targeting Syk) and HMPL-453 (targeting FGFR1/2/3); and
  2. Developing synthetic compounds against validated targets with clear differentiation to potentially be a global best-in-class/next generation therapy in their respective categories, including fruquintinib (targeting VEGFR1/2/3), HMPL-689 (targeting PI3Kδ), epitinib (targeting EGFR) and theliatinib (targeting EGFR wild type).

We have built our Innovation Platform into a productive global oncology and immunology drug research and development operation based in China. Our experienced research and development management team have all worked at multi-national pharmaceutical and biotechnology companies and have participated in the discovery and development of global blockbuster drugs, including Alimta?, Erbitux?, Gemzar?, Incivek?, Sutent?, Verzenio? and Zithromax ?. Together, they have systematically built a productive research and development team, which we believe is one of the largest in the oncology and immunology biotechnology space.

This represents a fully-integrated drug discovery and development organization covering chemistry, biology, pharmacology, toxicology, chemistry and manufacturing controls, clinical and regulatory and other functions, all of which work seamlessly together. We have a proven track record in internal discovery, with all our differentiated drug candidates having advanced into the clinic in the past 10 years.

大发快三98%中奖 | 下一页